Around 7pm Friday, police said the victim locked up his business premises in the West Bay area and drove to his home in Crescent Close.
He took a bag containing the cash into his home, leaving the front door open.
Police said the man was suddenly confronted by two men who are believed to have entered the house through the open door.
One of the suspects carried what appeared to be a firearm, police said. They threatened the man and forced him to lie on the floor before they ran off with the cash.
The suspects are believed to have made off from the scene a blue, two door, soft top vehicle, similar in shape to a Suzuki Sidekick.
No shots were fired and the victim was not injured.
Officers said the first suspect was described as being stocky and about 5′ 7″. He had a white shirt over his face and spoke with a Caymanian accent. The second man was about 5′ 5″ and wore a halloween mask, police said.
Anyone who was in the area at the relevant time and saw the suspects either entering or leaving the scene is asked to contact West Bay police station on 949-3999 or the confidential Crime Stoppers number 800-8477 (TIPS).