About 9.55am Friday, police attended the scene of a two-vehicle crash in Shamrock Road near Poindexter Road at the turn off to Prospect Primary School.
Police said the crash occurred when a Toyota Mark 11 travelling toward Grand Harbour collided with a Chevy truck, which was travelling toward Countryside Shopping Center in Savannah.
The male driver of the Toyota was cut free from his vehicle by the Cayman Islands Fire Service, police said. He sustained serious injuries in the crash.
The female driver of the Chevy sustained slight injuries. Both drivers were taken to the Cayman Islands Hospital where they were being treated.
A third vehicle at the scene was up on the bed of a tow truck, but police did not state whether it had been involved in the accident.